Does the location make the difference in predicting mediastinal spreading of clinical N0 non-small cell lung cancer?

Lung cancer is one of the worldwide “big killers”, being the first cause of death among malignant tumours (1). Mediastinal nodal disease is one of the most important predictive factor of survival in patients with non-small-cell lung cancer (NSCLC) and it guides clinicians in the decision of the proper treatment (2).