Recent years have seen a fast track of growth in surgical skills and techniques across the broad medical disciplines. This is tailed after by the repeatedly highlighted and renewed concepts such as minimally invasive surgery, medical artificial intelligence, precision medicine and multidisciplinary team. With an aim to exchange the vast knowledge across borders and expedite studies in cutting-edge surgical practices, the American College of Surgeons (ACS) Clinical Congress was held in Boston, MA, on October 21–25, 2018. Bringing together multi-disciplined surgeons, surgery residents, medical students and members of surgical teams from all over the world, the Congress sparked a whole bunch of ideas that is believed to benefit more patients worldwide.